The idiopathic or the primary Parkinsonism is the degenerative dis-order of the central nervous system in a person. In this type of disease the motor symptoms or the signs are the result of the death of the cells that generate dopamine in the substantianigra which is the area of the mid brain in an individual. The cause of the death of this cell is not known and in the pre-stage of this disease the most likely symptoms are related to the movement including the signs like shaking or the rigidity or the slowness of the movement and difficulty with walking and gait in the case of the person.
What Is Paralysis Agitans
In the later stages, the problems with the behavior and thinking may arise with dementia being the commonly occurring in the advanced stages of this disease. The other symptoms might be the sensory or the emotional ones being the most common in the elder people with most of the cases occurring after the age of fifty. The paralysis agitans can thus be considered as the dis-order of the nervous system in an individual.
Risk Factors Associated With Paralysis Agitans:-
Many protective and risk factors are involved in the case of paralysis agitans involving the risk of PD in the individuals exposed to certain pesticides and a less risk in the tobacco smokers. The disease is characterized by the deposition of proteins called alpha-synuclein into the inclusions called the lewy bodies in the neurons and from the in-adequate formation and the activity of dopamine that is formed in the certain neurons with the parts of the mid-brain.
The lewy bodies are the pathological hallmark of the idiopathic type of dies-order and the distribution of the lewy bodies throughout the Parkinson brain varies from one individual to the other. The astronomical distribution of the lewi bodies throughout the Parkinson brain varies from a person to The other and the distribution of these bodies is often related to the expression and the degree of The clinical symptoms of the every individual. The diagnosis is generally based on the symptoms with the tests such as the neuron –imaging that are being used for the confirmation.
The modern treatment approaches involve managing the early motor symptoms of the disease by the usage of levodopa and dopamine agonists as the disease progresses and dopaminergic neurons start getting lost, the usage of these drugs becomes more ineffective in treating the symptoms and at the same time to produce the compilation called dyskinesia that is marked by the in-voluntary writhing movements. There are also some of the medicines to treat the non-movement related problems.