Benzoyl peroxide / Benzoyl peroxide cream:-
Benzoyl peroxide proves to be a first-line treatment for mild and moderate acne due to its effectiveness and mild side-effects. It works against acnes and has anti-inflammatory properties.
Treatment and Management of Acne
Benzoyl peroxide normally causes dryness of the skin, slight redness, and occasional peeling when side effects occur. It increases sensitivity to the sun, so sunscreen use is often advised during the treatment to prevent sunburn. Benzoyl peroxide has been found to be nearly as effective as antibiotics with all concentrations being equally effective. Unlike antibiotics, benzoyl peroxide does not appear to generate bacterial resistance. Benzoyl peroxide is often combined with antibiotics.
Antibiotics OR Salicylic acid:-
Antibiotics are reserved for more severe cases and decrease acne due to their antimicrobial activity against acnes in conjunction with anti-inflammatory properties. With increasing resistance of acnes worldwide, they are becoming less effective. Commonly used antibiotics, either applied topically or taken orally, include erythromycin, clindamycin, metronidazole, and tetracyclines such as doxycycline and minocycline.
Topical erythromycin and clindamycin are considered safe to use as acne treatment during pregnancy due to negligible systemic absorption. Nadifloxacin, and are other topical antibiotics that may be used to treat acne in pregnant women, but have received less extensive study.
Salicylic acid helps to lessen acne due to its bacteriostatic and keratolytic properties. Additionally, salicylic acid can open obstructed skin pores and promotes shedding of epithelial skin cells. Hyperpigmentation of the skin has been observed in individuals with darker skin types who use salicylic acid.
In females, acne can be treated with the use of any combined oral contraceptive. The combinations that contain Tertiary or quardenary generation progestins such as desogestrel, norgestimate or drospirenone may theoretically be of more benefits. Antiandrogens such as cyproterone acetate and spironolactone have also been used successfully to treat acne.
Hormonal therapies should not be used to treat during pregnancy or lactation as they have been associated with certain birth defects such as hypospadias and feminization of the male fetus.
it refers to the usage of several curing therapies together in order to cure the disease. each with a different mechanism of action, demonstrated to be a more efficacious method to the treatment of this disease than monotherapy. Frequently used combinations include the following :- antibiotic + benzoyl peroxide, antibiotic + topical retinoid, or topical retinoid+ benzoyl peroxide.